Tom Brady kicked off his 20th season by throwing for 341 yards and three touchdowns as the Patriots beat down the Steelers 33-3 at Foxboro.
Ben Roethlisberger threw for 276 yards and an interception.
James Connor got just 10 carries for 21 yards. JuJu Smith-Schuster had six catches for 78 yards in the loss.
Chris Boswell got the team's only points with a 19-yard field goal to start the third quarter.
The Steelers will look to bounce back next week as the Seahawks visit Heinz Field.