Brock Nelson scored midway through overtime to give the Islanders a 5-4 win in Pittsburgh over the Penguins.
It was his second of the game. Brandon Tanev had a pair of goals for the Pens while Bryan Rust and Jake Guentzel each scored with the man advantage.
Matt Murray made 37 saves in the loss, Pittsburgh's third in four games.
The two teams will meet on the back end of a home and home tomorrow night in Brooklyn.