The Penguins lost for the second time in three days in overtime to the Islanders.
Brock Nelson scored two goals, including the game winner in overtime, as the Islanders nipped the Penguins 4-3 at Barclays Center.
Patric Hornqvist scored with 30 seconds remaining for Pittsburgh to send it into overtime.
Evgeni Malkin and Bryan Rust also lit the lamp for the Penguins, who are 1-1-and-3 in their last five. Pittsburgh opens a three-game homestand tonight against New Jersey.